Medical Supplies

114 rue Edouard Vaillant
94140 Alfortville
France

Phone: (+33-1)45181411
Fax: (+33-1)45181413
http://www.medisys-medical.com
medisys.medical@orange.fr
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Khadim Ali Road
51310 Sialkot
Pakistan

Phone: (+92-52)3553658
Fax: (+92-52)3554360
http://www.medisporex.com.pk
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PAE de Sorinnes, 1, route de la voie cuivrée
5503 Sorinnes
Belgium

Phone: (+32-82)223020
Fax: (+32-82)223334
http://www.medisoft.be
sales-marketing@medisoft.be
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Richard-Oskar-Mattern-Straße 6
40547 Düsseldorf
Germany

Phone: (+49-211)5382230
Fax: (+49-211)5382232
http://www.medisign.de
info@medisign.de
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Harrier Park, Southgate Way, Orton Southgate
PE2 6YQ Petersborough
United Kingdom

Phone: (+44-1733)361414
Fax: (+44-1733)361121
http://www.medisavers.co.uk
sales@medisavers.co.uk

Company Contacts
Department/ Name Address

Sales Office Manager - Eain McAlinden Direct Line: 01733 36 11 21, Tel: 01733 36 14 14, Fax: 01733 36 11 21, Mobile: 07939 851406
e.mcalinden@medisavers.co.uk
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Lanzahita, 6
28946 Madrid
Spain

Phone: (+34-91)2089410
Fax: (+34-91)2089401
http://www.medical-iberica.com
export@medical-iberica.com
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Unit 7, The Gateway Centre,
HP12 3SU High Wycombe
United Kingdom

Phone: (+44-1494)551200
Fax: (+44-1494)536333
http://www.mediplus.co.uk
export@mediplus.co.uk
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H-10, 10th Floor, Big Jo’s Tower, Netaji Subash Place
110 034 New Delhi
India

Phone: (+91-273)53189
Fax: (+91-11)47082818
http://www.mediplusdisposables.com
info@mediplusdisposables.com

Company Contacts
Department/ Name Address

Mediplus (India) Ltd. 1261-1262, M.I.E. Bahadurgarh-124507, Haryana, India
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Ludwig-Erhard-Ring 3
15827 Dahlewitz
Germany

Phone: (+49-33708)4417-0
Fax: (+49-33708)4417-25
http://www.medipan.de
info@medipan.de

Company Contacts
Department/ Name Address

Marketing / Christian Dübel MEDIPAN GMBH, Ludwig-Erhard-Ring 3, 15827 Dahlewitz / Berlin, Tel.: +49 (0) 33 708 44 17 27, Fax: +49 (0) 33 708 44 17 25
c.duebel@medipan.de Germany

Company Figures
Number of employees 20-49
Sales volume 1-9 Mio US $
Export content max. 50%
Year of foundation 1992
Area of business Diagnostics

Language: German Language: English Company Profile

Diagnostics for thyroid diseases and autoimmune diabetes
Since more than 12 years MEDIPAN is the reliable partner for the diagnostics of thyroid disease and autoimmune diabetes. Proven kits are provided in RIA and ELISA format. The main focus is on the diagnosis of Graves’ disease and the early detection of recurrence of thyroid carcinoma.

Product Information
03.01.08 Devices and systems for glucose determination units

03.01.08.06 Glucose fully automatic determination

03.02.03 Auto-immune diseases

03.02.03.01 Diagnostics / kits for the diabetes analyses
Diabetes diagnostics 02.11.2007

The classification of type 1 diabetes (insulin dependent diabetes mellitus) is complicated by the fact that it is based on clinical symptoms rather than etiology. Both environment and genetics contribute to the pathophysiology. Type 1 diabetes is an organ specific disease with an apparent immune response to pancreatic islets.

The loss of ß-cells of the pancreatic islets is associated with multiple immunpathologic phenomena, best reflected by the appearance of autoantibodies to one or more of the following islet autoantigens: the 65 kDa isoform of glutamic acid decarboxylase (GAD65), the islet cell antigen IA2 (ICA512), or insulin itself.

Islet autoantibodies are considered the best immune markers of this disease so far. Molecular techniques yielding recombinant antigens have been used to establish reproducible and precise autoantibody assays recently. Autoantibodies to GAD 65, IA2 and Insulin can be detected in human serum many years before clinical onset of the disease.

The enzyme glutamic acid decarboxylase (GAD65) was the first autoantigen defined by genetic engineering and made available for diagnostic purposes. IA2, the second discovered islet cell antigen, is a member of the protein tyrosine phosphatase family and localized in dense granules of pancreatic ß-islet cells.

Insulin autoantibodies (IAA) can be found in sera of patients prone to type 1 diabetes before onset of the disease and insulin therapy. IAA are of high predicitive value for type 1 diabetes in early childhood and young age. Thus, it is recommended to include the determination of IAA in primary testing of children under 10 years to maximize sensitivity.

The simultaneous presence of all three antibodies strongly predicts type 1 diabetes in first-degree relatives of individuals with the disease. Diagnostic sensitivity of islet autoantibodies for type 1 diabetes is strongly dependent on age of onset. IAA and IA2 autoantibodies occur more frequently in children than in adult patients. Conversely, GAD 65 autoantibody is the marker with the highest diagnostic sensitivity for adult type 1 diabetes patients and may be used to discriminate between type 2 diabetes and so called latent diabetes or latent autoimmune diabetes in adults (LADA).

03.02.03.03 Diagnostics / kits for the thyroid gland analyses
Thyroid diseases diagnostics 02.11.2007

Secretion of thyroid hormones (T4, T3) plays an important role in the homeostasis regulated by the thyroid-stimulating hormon (TSH). TSH synthesis and release by the pituitary gland is controlled by circulating levels of T4 and T3 and by the hypothalamic thyrotropin-releasing hormone (TRH). The thyroid hormones regulate the TSH secretion by negative feed-back mechanism. Therefore, an increased serum TSH is for example the earliest and best indicator of primary hypothyroidism. Measurement of thyroid hormone and TSH levels is used to diagnose hypothyroidism and hyperthyroidism. In contrast thyroid antibody tests are employed to determine if a thyroid disfunction is linked with autoimmune thyroid diseases (AITD).

AITD refers to a number of different disorders in which the immune system either targets or attacks cells of the thyroid gland, causing symptoms of thyroid disease. AITD includes both hypothyroidism (reduced thyroid hormone synthesis) and hyperthyroidism, caused by excess thyroid hormon production.

The most common AITD are:

• Hashimoto’s thyroiditis (autoimmune thyroiditis), a disorder of hypothyroidism;

• Graves’ disease The TSH receptor (TSH-R) is one of the major autoantigens in autoimmune thyroid disease, and autoantibodies acting as TSH-R agonists lead to the clinical symptoms of Graves’disease;

• Primary myxedema or autoimmune thyroid failure, a hypothyroid disorder caused by thyroid cell destruction.

AITD are characterized by the occurence of antibodies against several antigens in the thyroid gland, especially against the TSH receptor (TSH-R), thyroperoxidase (anti-TPO) and thyroglobulin (anti-Tg). Patients with AITD usually have a combination of different thyroid autoantibodies. The detection of thyroid autoantibodies is an integral part of the differential diagnosis of AITD in particular for differentiation of AITD from diseases with autonomously functioning thyroid tissue.

Thyroglobulin (Tg), the precursor protein for thyroid hormon synthesis, is organ and tissue specific for the thyroid gland. Therefore, the main indication of serum Tg is the monitoring of patients with differentiated thyroid cancer (DTC) after total thyroidectomy and ablative radioiodine treatment.

The preoperative serum Tg measurement reflects the tumor ability to secrete Tg and validates the use of serum Tg as a postoperative tumor marker. Increasing Tg values indicates recurrence of DTC. The determination of serum Tg can also be useful to distinguish between subacute thyroiditis and factitious thyrotoxicosis and for differential diagnosis of neonatal hypothyroidism.

03.02.06 Thyroid function hormones

03.02.06.01 Diagnostic agents / kits for thyroid gland, etc. determination

03.02.07 Immuno assay systems

03.02.07.06 Enzyme immunoassay (EIA, ELISA, EMIT)

03.02.07.21 Radioimmunoassay (RIA)

03.05.05 Equipment and systems for microbiological diagnosis/virology

03.05.05.02 Equipment for microbiological diagnosis

Viale Cembrano, 4C
16148 Genova
Italy

Phone: (+39-010)3071634
Fax: (+39-010)3074548
http://www.medimatic.com
info@medimatic.it

Company Contacts
Department/ Name Address

R & D - Simone Ursino Viale Cembrano 4C, 16148 Genova, Italy
sursino@medimatic.it

Sales & Marketing - Maurizio Piaggio Viale Cembrano 4C, 16148 Genova, Italy
mpiaggio@medimatic.it
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